Western Blot (WB)
(Western blot analysis of extracts from 293 cells, using ALX3 antibody.)
Rabbit ALX3 Polyclonal Antibody | anti-ALX3 antibody
ALX3 Antibody
Immunofluorescence: 1:100~1:500
Western Blot (WB)
(Western blot analysis of extracts from 293 cells, using ALX3 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from 293 cells, using ALX3 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cells, using ALX3 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cells, using ALX3 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
Uniprot Description
ALX3: Transcriptional regulator with a possible role in patterning of mesoderm during development. Defects in ALX3 are the cause of frontonasal dysplasia type 1 (FND1); also called frontonasal malformation (FNM) or frontorhiny. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.
Protein type: Transcription, coactivator/corepressor; DNA-binding
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: regulation of apoptosis; embryonic forelimb morphogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; embryonic hindlimb morphogenesis; pattern specification process; embryonic skeletal morphogenesis
Disease: Frontonasal Dysplasia 1
Research Articles on ALX3
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Product Notes
The ALX3 alx3 (Catalog #AAA9410157) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ALX3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ALX3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Western blotting: 1:500~1:3000 Immunofluorescence: 1:100~1:500. Researchers should empirically determine the suitability of the ALX3 alx3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALX3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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