Rabbit Alpha-Tubulin Cleaved By Caspase-6 Polyclonal Antibody
Alpha-Tubulin Cleaved By Caspase-6 Rabbit Polyclonal Antibody
Applications
Immunohistochemistry, Western Blot
Synonyms
Alpha-Tubulin Cleaved By Caspase-6; Polyclonal Antibody; Alpha-Tubulin Cleaved By Caspase-6 Rabbit Polyclonal Antibody; a-Tubulin cleaved by casp 6; anti-Alpha-Tubulin Cleaved By Caspase-6 antibody
Host
Rabbit
Clonality
Polyclonal
Specificity
The antibody recognizes the sequence (EEVGVD) in tubulin protein. It is specific for Caspase 6 cleaved a-Tubulin. The antibody was tested in IHC and western blots of samples with Alzheimer disease (AD) (Bovine brain sample, human samples, cells lines, mice hippocampus and whole brains). When tested in null mice with IHC and WB, no immunoreactivity was observed.
Form/Format
Lyophilized serum
Applicable Applications for anti-Alpha-Tubulin Cleaved By Caspase-6 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes
If reconstituted with deionized water in 50 ul: WB 1:1000; IHC 1:1000.
Optimal dilution has to be determined by the user.
Optimal dilution has to be determined by the user.
Preservative
None
Target
Tubulin cleaved by caspase-6
Target Alias
α-Tubulin cleaved by casp 6
Immunogen
EEVGVD peptide
Note
To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verifiy if those preservatives are compatible with your assay.
Preparation and Storage
Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconst ituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
Related Product Information for anti-Alpha-Tubulin Cleaved By Caspase-6 antibody
Tubulin is the major constituent of microtubules. Microtubules are assembled from dimers of α-and β-tubulin. α-Tubulin cleaved by caspase-6 can be found in neurons, neurofibrillary tangles, neutrophil threads, and neuritic plaques in Alzheimer disease. α-Tubulin has been found to associate with the axonal microtubule-associated protein Tau, indicating that the cleavage of the functional α-Tubulin C-terminal domain by caspase-6 could alter the state of microtubules in neurons.
References
1. Klaiman G-Targets of caspase-6 activity in human neurons and Alzheimer disease.
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Product Notes
The Alpha-Tubulin Cleaved By Caspase-6 (Catalog #AAA588220) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Alpha-Tubulin Cleaved By Caspase-6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). If reconstituted with deionized water in 50 ul: WB 1:1000; IHC 1:1000. Optimal dilution has to be determined by the user. Researchers should empirically determine the suitability of the Alpha-Tubulin Cleaved By Caspase-6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Alpha-Tubulin Cleaved By Caspase-6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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