Western Blot (WB)
(Western blot analysis of ALKB expression in HT29 (A), MCF7 (B) whole cell lysates.)
Rabbit anti-Human ALKB Polyclonal Antibody | anti-ALKBH1 antibody
Anti-ALKB Antibody
Western Blot (WB)
(Western blot analysis of ALKB expression in HT29 (A), MCF7 (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of ALKB expression in HT29 (A), MCF7 (B) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]
Uniprot Description
ALKBH: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. Belongs to the alkB family.
Protein type: EC 4.2.99.18; EC 1.14.11.33; DNA repair, damage
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: mitochondrion
Molecular Function: chemoattractant activity; DNA-(apurinic or apyrimidinic site) lyase activity; ferrous iron binding
Biological Process: developmental growth; DNA dealkylation; DNA repair; in utero embryonic development; negative regulation of neuron apoptosis; neurite development; neuron migration; placenta development; positive chemotaxis; regulation of gene expression; RNA repair
Research Articles on ALKBH1
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Product Notes
The ALKBH1 alkbh1 (Catalog #AAA8245357) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ALKB Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ALKB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1/500 - 1/2000. Researchers should empirically determine the suitability of the ALKBH1 alkbh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALKB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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