Western Blot (WB)
(Western Blot analysis of ALDH7A1 in Human fetal liver tissue and Human liver tissue, Hela, HepG2 and A172 cell, Rat liver tissue lysates in order using ALDH7A1 Rabbit pAb at dilution 1/400)
Rabbit ALDH7A1 Polyclonal Antibody | anti-ALDH7A1 antibody
ALDH7A1 Rabbit pAb
IHC-P: 1:20-1:100
Western Blot (WB)
(Western Blot analysis of ALDH7A1 in Human fetal liver tissue and Human liver tissue, Hela, HepG2 and A172 cell, Rat liver tissue lysates in order using ALDH7A1 Rabbit pAb at dilution 1/400)
Western Blot (WB)
(Western Blot analysis of ALDH7A1 in Human fetal liver tissue and Human liver tissue, Hela, HepG2 and A172 cell, Rat liver tissue lysates in order using ALDH7A1 Rabbit pAb at dilution 1/400)
Immunohistochemistry (IHC)
(Immunohistochemistry of ALDH7A1 in paraffin-embedded Human esophagus cancer tissue using ALDH7A1 Rabbit pAb at dilution 1/25. Predicted cell location: Cytoplasm)
Immunohistochemistry (IHC)
(Immunohistochemistry of ALDH7A1 in paraffin-embedded Human esophagus cancer tissue using ALDH7A1 Rabbit pAb at dilution 1/25. Predicted cell location: Cytoplasm)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]
Uniprot Description
ALDH7A1: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. Defects in ALDH7A1 are the cause of pyridoxine-dependent epilepsy (PDE). PDE is characterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride. Belongs to the aldehyde dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; EC 1.2.1.31; EC 1.2.1.8; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion
Molecular Function: aldehyde dehydrogenase (NAD) activity; betaine-aldehyde dehydrogenase activity; L-aminoadipate-semialdehyde dehydrogenase activity; protein binding
Biological Process: aldehyde metabolic process; choline catabolic process; lysine catabolic process; sensory perception of sound
Disease: Epilepsy, Pyridoxine-dependent
Research Articles on ALDH7A1
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Product Notes
The ALDH7A1 aldh7a1 (Catalog #AAA4760855) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ALDH7A1 Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ALDH7A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:200-1:1000 IHC-P: 1:20-1:100. Researchers should empirically determine the suitability of the ALDH7A1 aldh7a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALDH7A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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