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Testing Data (Fig-1: Expression analysis of ALDH1A1. Anti-ALDH1A1 antibody (11-7549) was used at 1 ug/ml on HepG2 lysate.)

Rabbit anti-Human ALDH1A1 Polyclonal Antibody | anti-ALDH1A1 antibody

Polyclonal Antibody to ALDH1A1

Gene Names
ALDH1A1; ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e
Reactivity
Human
Applications
Western Blot
Purity
Purified
Protein A Chromatography
Synonyms
ALDH1A1; Polyclonal Antibody; Polyclonal Antibody to ALDH1A1; ALDC; ALDH1; PUMB1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase; cytosolic; Antibody to ALDH1A1; Anti-ALDH1A1 Antibody; ALDH1A1 Antibody; anti-ALDH1A1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified
Protein A Chromatography
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Sequence Length
501
Applicable Applications for anti-ALDH1A1 antibody
Western Blot (WB)
Application Notes
WB: 1-2 ug/ml
Immunogen Information
A partial length recombinant ALDH1A1 protein (amino acids 284-492) was used as the immunogen for this antibody.
Antigen
ALDH1A1
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.

Testing Data

(Fig-1: Expression analysis of ALDH1A1. Anti-ALDH1A1 antibody (11-7549) was used at 1 ug/ml on HepG2 lysate.)

Testing Data (Fig-1: Expression analysis of ALDH1A1. Anti-ALDH1A1 antibody (11-7549) was used at 1 ug/ml on HepG2 lysate.)
Related Product Information for anti-ALDH1A1 antibody
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a superfamily of detoxification enzymes found in various tissues that participate in the oxidation of both aliphatic and aromatic aldehydes. The human ALDH1A1, which is tetrameric and predominantly of cytosolic origin, functions mainly in acetaldehyde and neurotransmitter metabolism. It is also reported to play a major role in the production of retinoic acid, which is important for gene expression and tissue differentiation, and also in cyclophosphamide detoxification. ALDH1A1 is found in various tissues, including the central nervous system (CNS), with highest levels in the liver. In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepinephrine, and is uniquely expressed in a subset of dopaminergic (DAergic) neurons in the ventral mesencephalon where it converts 3, 4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3, 4-dihydroxyphenylacetic acid, a non toxic metabolite. ALDHA1 has been implicated in the development of alcohol dependence and other alcohol-use disorders, alcohol-induced flushing and sensitivity to alcohol.
Product Categories/Family for anti-ALDH1A1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
216
UniProt Accession #
Molecular Weight
54,862 Da
NCBI Official Full Name
Retinal dehydrogenase 1
NCBI Official Synonym Full Names
aldehyde dehydrogenase 1 family member A1
NCBI Official Symbol
ALDH1A1
NCBI Official Synonym Symbols
ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e
NCBI Protein Information
retinal dehydrogenase 1
UniProt Protein Name
Retinal dehydrogenase 1
Protein Family
UniProt Gene Name
ALDH1A1
UniProt Synonym Gene Names
RALDH 1Curated; RalDH1Curated

NCBI Description

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

Uniprot Description

ALDH1A1: Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family.

Protein type: Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; androgen binding; benzaldehyde dehydrogenase (NAD+) activity; GTPase activator activity; retinal dehydrogenase activity

Biological Process: aldehyde metabolic process; ethanol oxidation; retinoid metabolic process

Research Articles on ALDH1A1

Similar Products

Product Notes

The ALDH1A1 aldh1a1 (Catalog #AAA668498) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to ALDH1A1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ALDH1A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1-2 ug/ml. Researchers should empirically determine the suitability of the ALDH1A1 aldh1a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALDH1A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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