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Rabbit AKR1B1 Polyclonal Antibody | anti-AKR1B1 antibody

AKR1B1 Antibody BIOTIN-Conjugated

Gene Names
AKR1B1; AR; ADR; ALR2; ALDR1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Synonyms
AKR1B1; Polyclonal Antibody; AKR1B1 Antibody BIOTIN-Conjugated; ADR; AKR1B 1; Aldehyde reductase; Aldo keto reductase family 1; member B1; Aldose reductase; aldr 1; ALR2; AR; Lii5 2 CTCL tumor antigen; low Km aldose reductase; MGC1804 antibody; anti-AKR1B1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Form/Format
BIOTIN-Conjugated
Concentration
0.55-0.75 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
316
Applicable Applications for anti-AKR1B1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
Immunogen
Synthetic peptide taken within amino acid region 250-350 on human Aldo-keto reductase family 1, member B1 protein.
Expression
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Molecular Function
Aldo-keto reductase (NADP) activity, glyceraldehyde oxidoreductase activity, electron carrier activity
Structure
Monomer
Subcellular Location
Cytoplasm
Preparation and Storage
-20 degree C for long term storage
Related Product Information for anti-AKR1B1 antibody
BIOTIN-Conjugated Aldo-keto reductase family 1, member B1 Antibody
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
231
UniProt Accession #
Molecular Weight
35,853 Da
NCBI Official Full Name
Aldo-keto reductase family 1, member B1 (aldose reductase)
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member B
NCBI Official Symbol
AKR1B1
NCBI Official Synonym Symbols
AR; ADR; ALR2; ALDR1
NCBI Protein Information
aldose reductase
UniProt Protein Name
Aldose reductase
Protein Family
UniProt Gene Name
AKR1B1
UniProt Synonym Gene Names
ALDR1; AR
UniProt Entry Name
ALDR_HUMAN

NCBI Description

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Uniprot Description

AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - pyruvate; EC 1.1.1.21; Oxidoreductase; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - galactose

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: cytoplasm; cytosol; extracellular space; mast cell granule; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; glyceraldehyde oxidoreductase activity

Biological Process: C21-steroid hormone biosynthetic process; carbohydrate metabolic process; fructose biosynthetic process; maternal process involved in pregnancy; naphthalene metabolic process; norepinephrine metabolic process; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; response to stress; response to water deprivation; sorbitol biosynthetic process; stress-activated protein kinase signaling pathway; tissue homeostasis

Research Articles on AKR1B1

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Product Notes

The AKR1B1 akr1b1 (Catalog #AAA540962) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AKR1B1 Antibody BIOTIN-Conjugated reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's AKR1B1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the AKR1B1 akr1b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AKR1B1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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