Rabbit AKR1A1 Polyclonal Antibody | anti-AKR1A1 antibody

AKR1A1 Rabbit Polyclonal

Cat. Num. AAA766492

• Gene Names: AKR1A1; ALR; ARM; DD3; ALDR1; HEL-S-6
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: AKR1A1; Polyclonal Antibody; AKR1A1 Rabbit Polyclonal; anti-AKR1A1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 325

• Applicable Applications for anti-AKR1A1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Aldo-keto reductase family 1, member A1 (aldehyde reductase)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat kidney using MBS766492 (AKR1A1 antibody) at dilution of 1:100)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS766492 (AKR1A1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 320202988
• NCBI GeneID: 10327
• NCBI Accession #: NP_001189342.1
• NCBI GenBank Nucleotide #: NM_001202413.1
• Molecular Weight: 36,573 Da
• NCBI Official Full Name: alcohol dehydrogenase
• NCBI Official Synonym Full Names: aldo-keto reductase family 1 member A1
• NCBI Official Symbol: AKR1A1
• NCBI Official Synonym Symbols: ALR; ARM; DD3; ALDR1; HEL-S-6
• NCBI Protein Information: alcohol dehydrogenase [NADP(+)]
• UniProt Protein Name: Alcohol dehydrogenase [NADP(+)]
• Protein Family: Alcohol dehydrogenase
• UniProt Gene Name: AKR1A1
• UniProt Synonym Gene Names: ALDR1; ALR
• UniProt Entry Name: AK1A1_HUMAN

NCBI Description

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

Uniprot Description

AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family.

Protein type: Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid; EC 1.1.1.2

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: apical plasma membrane; cytosol; extracellular space

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; L-glucuronate reductase activity; protein binding

Biological Process: aldehyde catabolic process; aldehyde metabolic process; D-glucuronate catabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate; L-ascorbic acid biosynthetic process