Goat AKAP9/YOTIAO Polyclonal Antibody | anti-AKAP9 antibody
Goat anti-AKAP9/YOTIAO Antibody
Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of 453kDa according to NP_005742.4. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.
NCBI and Uniprot Product Information
NCBI Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]
Uniprot Description
AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: centrosome; cis-Golgi network; cytoskeleton; cytosol; Golgi apparatus; Golgi stack; intracellular membrane-bound organelle; voltage-gated potassium channel complex
Molecular Function: potassium channel regulator activity; protein binding; protein complex scaffold; Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: G2/M transition of mitotic cell cycle; MAPKKK cascade; microtubule nucleation; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; signal transduction; synaptic transmission; transport
Disease: Long Qt Syndrome 11
Research Articles on AKAP9
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Product Notes
The AKAP9 akap9 (Catalog #AAA421869) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-AKAP9/YOTIAO Antibody reacts with Expected from sequence similarity: Human, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's AKAP9/YOTIAO can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of 453kDa according to NP_005742.4. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product. Researchers should empirically determine the suitability of the AKAP9 akap9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: QRKAQSDGQS PSKK. It is sometimes possible for the material contained within the vial of "AKAP9/YOTIAO, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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