Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using MBS766481 (AKAP1 Antibody) at dilution of 1:50)
Rabbit anti-Human AKAP1 Polyclonal Antibody | anti-AKAP1 antibody
AKAP1 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using MBS766481 (AKAP1 Antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using MBS766481 (AKAP1 Antibody) at dilution of 1:50)
Testing Data
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Testing Data
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Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS766481 (AKAP1 antibody) at dilution of 1:1000)
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS766481 (AKAP1 antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Uniprot Description
AKAP1: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Adaptor/scaffold; RNA-binding; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: cytosol; integral to membrane; lipid particle; membrane; mitochondrial crista; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; neuromuscular junction; postsynaptic membrane
Molecular Function: beta-tubulin binding; microtubule binding; protein binding; protein complex scaffold; protein domain specific binding; protein kinase binding; protein phosphatase 2B binding; RNA binding
Biological Process: blood coagulation; negative regulation of NFAT protein import into nucleus; negative regulation of protein amino acid dephosphorylation
Research Articles on AKAP1
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Product Notes
The AKAP1 akap1 (Catalog #AAA766481) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AKAP1 Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AKAP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the AKAP1 akap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AKAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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