Western Blot (WB)
(Western Blot analysis of AIM2 expression in transfected 293T cell line by AIM2 polyclonal antibody. Lane 1: AIM2 transfected lysate (39kD). Lane 2: Non-transfected lysate.)
Rabbit AIM2 Polyclonal Antibody | anti-AIM2 antibody
AIM2 (Interferon-inducible Protein AIM2, Absent in Melanoma 2, PYHIN4) (PE)
Western Blot (WB)
(Western Blot analysis of AIM2 expression in transfected 293T cell line by AIM2 polyclonal antibody. Lane 1: AIM2 transfected lysate (39kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of AIM2 expression in transfected 293T cell line by AIM2 polyclonal antibody. Lane 1: AIM2 transfected lysate (39kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
Uniprot Description
AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; double-stranded DNA binding
Biological Process: positive regulation of protein oligomerization; positive regulation of interleukin-1 beta production; tumor necrosis factor-mediated signaling pathway; apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; immune response; interleukin-1 beta secretion; positive regulation of interleukin-1 beta secretion; inflammatory response; positive regulation of defense response to virus by host; activation of innate immune response; activation of NF-kappaB transcription factor
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Product Notes
The AIM2 aim2 (Catalog #AAA6369186) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AIM2 (Interferon-inducible Protein AIM2, Absent in Melanoma 2, PYHIN4) (PE) reacts with Human, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's AIM2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the AIM2 aim2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AIM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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