Rabbit anti-Human AGXT2L2 Polyclonal Antibody | anti-AGXT2L2 antibody

AGXT2L2 polyclonal antibody

Cat. Num. AAA3014779

• Gene Names: PHYKPL; PHLU; AGXT2L2
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Synonyms: AGXT2L2; Polyclonal Antibody; AGXT2L2 polyclonal antibody; 5-phosphohydroxy-L-lysine phospho-lyase; Alanine--glyoxylate aminotransferase 2-like 2; PHYKPL; PP9286; anti-AGXT2L2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: AGXT2L2 polyclonal antibody detects endogenous levels of AGXT2L2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-AGXT2L2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:200
• Immunogen: Synthetic peptide, corresponding to Human AGXT2L2
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of AGXT2L2 polyclonal antibody at 1:500 dilutionLaneA: The Kidney tissue lysate of MouseLaneB: The Kidney tissue lysate of Mouse)

Related Product Information for anti-AGXT2L2 antibody

5-phosphohydroxy-L-lysine phospho-lyase, catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde.

NCBI and Uniprot Product Information

• NCBI GI #: 24119277
• NCBI GeneID: 85007
• NCBI Accession #: NP_699204.1
• NCBI GenBank Nucleotide #: NM_153373.3
• UniProt Accession #: Q8IUZ5; Q8WYS6; Q96HW8; B3KN36; D3DWP9
• Molecular Weight: 49,711 Da
• NCBI Official Full Name: 5-phosphohydroxy-L-lysine phospho-lyase isoform 2
• NCBI Official Synonym Full Names: 5-phosphohydroxy-L-lysine phospho-lyase
• NCBI Official Symbol: PHYKPL
• NCBI Official Synonym Symbols: PHLU; AGXT2L2
• NCBI Protein Information: 5-phosphohydroxy-L-lysine phospho-lyase; 5-phosphonooxy-L-lysine phospho-lyase; alanine-glyoxylate aminotransferase 2-like 2; alanine--glyoxylate aminotransferase 2-like 2
• UniProt Protein Name: 5-phosphohydroxy-L-lysine phospho-lyase
• UniProt Gene Name: AGXT2L2
• UniProt Entry Name: AT2L2_HUMAN

NCBI Description

This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Description

AGXT2L2: Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 4.2.3.134

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: mitochondrion

Molecular Function: lyase activity; transaminase activity; pyridoxal phosphate binding

Biological Process: metabolic process

Disease: Phosphohydroxylysinuria