Rabbit anti-Human, Mouse AGXT Polyclonal Antibody | anti-AGXT antibody

AGXT Rabbit Polyclonal

Cat. Num. AAA766456

• Gene Names: AGXT; AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1
• Reactivity: Human, Mouse
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: AGXT; Polyclonal Antibody; AGXT Rabbit Polyclonal; anti-AGXT antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 392

• Applicable Applications for anti-AGXT antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Immunogen: Alanine-glyoxylate aminotransferase
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver slide using MBS766456 (AGXT Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS766456 (AGXT antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 823674342
• NCBI GeneID: 189
• Molecular Weight: 43,010 Da
• NCBI Official Full Name: AGXT, partial
• NCBI Official Synonym Full Names: alanine-glyoxylate aminotransferase
• NCBI Official Symbol: AGXT
• NCBI Official Synonym Symbols: AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1
• NCBI Protein Information: serine--pyruvate aminotransferase
• UniProt Protein Name: Serine--pyruvate aminotransferase
• Protein Family: Serine--pyruvate aminotransferase
• UniProt Gene Name: AGXT
• UniProt Synonym Gene Names: AGT1; SPAT; SPT; AGT
• UniProt Entry Name: SPYA_HUMAN

NCBI Description

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]

Uniprot Description

AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Protein type: EC 2.6.1.51; Transferase; Mitochondrial; EC 2.6.1.44; Amino Acid Metabolism - alanine, aspartate and glutamate; Motility/polarity/chemotaxis; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: mitochondrial matrix; peroxisomal matrix; peroxisome

Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity

Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus

Disease: Hyperoxaluria, Primary, Type I