Rabbit AGTR1 Polyclonal Antibody | anti-AGTR1 antibody

AGTR1 (Angiotensin II Type-1 Receptor, AT1, AG2S, AT1B, AT1R, AT1AR, AT1BR, AT2R1, HAT1R, AGTR1A, AGTR1B, AT2R1A, AT2R1B) (Biotin)

Cat. Num. AAA6405818

• Gene Names: AGTR1; AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1A; AGTR1B; AT2R1A; AT2R1B
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: AGTR1; Polyclonal Antibody; AGTR1 (Angiotensin II Type-1 Receptor; AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1A; AGTR1B; AT2R1A; AT2R1B) (Biotin); anti-AGTR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes AGTR1. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-AGTR1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human AGTR1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of 231 cell line, using AGTR1 antibody.)

Product Categories/Family for anti-AGTR1 antibody

Antibodies; Angiotensin(ogen)

NCBI and Uniprot Product Information

• NCBI GI #: 4501997
• NCBI GeneID: 185
• NCBI Accession #: NP_000676.1
• NCBI GenBank Nucleotide #: NM_000685.4
• UniProt Accession #: P30556; Q13725
• Molecular Weight: 41,061 Da
• NCBI Official Full Name: type-1 angiotensin II receptor isoform 1
• NCBI Official Synonym Full Names: angiotensin II receptor, type 1
• NCBI Official Symbol: AGTR1
• NCBI Official Synonym Symbols: AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1A; AGTR1B; AT2R1A; AT2R1B
• NCBI Protein Information: type-1 angiotensin II receptor; type-1B angiotensin II receptor
• UniProt Protein Name: Type-1 angiotensin II receptor
• Protein Family: Type-1 angiotensin II receptor
• UniProt Gene Name: AGTR1
• UniProt Synonym Gene Names: AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1
• UniProt Entry Name: AGTR1_HUMAN

NCBI Description

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; angiotensin type II receptor activity; protein heterodimerization activity; angiotensin type I receptor activity; bradykinin receptor binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vasodilation; positive regulation of cellular protein metabolic process; renin-angiotensin regulation of aldosterone production; calcium-mediated signaling; regulation of systemic arterial blood pressure by renin-angiotensin; Rho protein signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; renin-angiotensin regulation of blood vessel size; regulation of vasoconstriction; regulation of inflammatory response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of cell growth; kidney development; positive regulation of phospholipase A2 activity; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity

Disease: Renal Tubular Dysgenesis; Hypertension, Essential