Testing Data
(Gel: 6%SDS-PAGE Lysates (from left to right): Raji, 293T and PC3 cell Amount of lysate: 40ug per lane Primary antibody: 1/450 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute)
Rabbit anti-Human, Mouse AGO4 Polyclonal Antibody | anti-AGO4 antibody
AGO4 Antibody
Testing Data
(Gel: 6%SDS-PAGE Lysates (from left to right): Raji, 293T and PC3 cell Amount of lysate: 40ug per lane Primary antibody: 1/450 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute)
Testing Data
(Gel: 6%SDS-PAGE Lysates (from left to right): Raji, 293T and PC3 cell Amount of lysate: 40ug per lane Primary antibody: 1/450 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]
Uniprot Description
AGO4: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Belongs to the argonaute family. Ago subfamily.
Protein type: Translation initiation; Translation
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: membrane; cytoplasm; cytosol
Molecular Function: protein binding; miRNA binding
Biological Process: epidermal growth factor receptor signaling pathway; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; miRNA-mediated gene silencing, mRNA cleavage; mRNA catabolic process; innate immune response; miRNA-mediated gene silencing, negative regulation of translation; gene expression; posttranscriptional gene silencing
Research Articles on AGO4
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Product Notes
The AGO4 ago4 (Catalog #AAA9410410) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AGO4 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's AGO4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500-1:2000. Researchers should empirically determine the suitability of the AGO4 ago4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AGO4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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