Western Blot (WB)
(AEBP1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).)
Rabbit anti-Human, mouse AEBP1 Polyclonal Antibody | anti-AEBP1 antibody
AEBP1 Antibody (Center)
Western Blot (WB)
(AEBP1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).)
Western Blot (WB)
(AEBP1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).)
Western Blot (WB)
(AEBP1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).)
Western Blot (WB)
(AEBP1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).)
transcriptional repressor with carboxypeptidase (CP) activity. This
protein binds to a regulatory sequence, adipocyte enhancer 1
(AE-1), located in the proximal promoter region of the adipose P2
(aP2) gene, which encodes the adipocyte fatty-acid binding protein.
It is characterized as a member of the regulatory B-like CP family.
This protein seems to be activated by a novel mechanism, whereby
the direct binding of DNA enhances its protease activity.
Adipocyte-enhancer binding protein 1 may play a role in
differentiated vascular smooth muscle cells.
Schissel, S.L., et al. Am. J. Pathol. 174(3):818-828(2009)
Zhang, L., et al. Mol. Med. 11 (1-12), 39-47 (2005) :
Layne, M.D., et al. Mol. Cell. Biol. 21(15):5256-5261(2001)
Muise, A.M., et al. Biochem. J. 343 PT 2, 341-345 (1999) :
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
Uniprot Description
AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7p13
Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus
Molecular Function: calmodulin binding; zinc ion binding; carboxypeptidase activity; transcription corepressor activity; transcription factor activity; metallocarboxypeptidase activity
Biological Process: muscle development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; proteolysis; skeletal development
Research Articles on AEBP1
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Product Notes
The AEBP1 aebp1 (Catalog #AAA9207317) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 334-364. The AEBP1 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's AEBP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the AEBP1 aebp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AEBP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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