Rabbit anti-Mouse Adrenergic Receptor Beta 2 (ADRb2) Polyclonal Antibody | anti-ADRb2 antibody
HRP-Linked Polyclonal Antibody to Adrenergic Receptor Beta 2 (ADRb2)
IHC: 5-20ug/mL
ICC: 5-20ug/mL
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
NCBI Description
This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
Uniprot Description
ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Cellular Component: apical plasma membrane; axon; caveola; cytoplasm; dendrite; dendritic spine; endosome; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane; receptor complex; sarcolemma
Molecular Function: adenylate cyclase binding; adrenoceptor activity; B2 bradykinin receptor binding; beta2-adrenergic receptor activity; dopamine binding; drug binding; enzyme binding; epinephrine binding; G-protein alpha-subunit binding; G-protein coupled receptor activity; ionotropic glutamate receptor binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein complex binding; protein homodimerization activity; signal transducer activity
Biological Process: adenylate cyclase activation; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; associative learning; bone resorption; brown fat cell differentiation; cell-cell signaling; diaphragm contraction; diet induced thermogenesis; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; heat generation; negative regulation of angiogenesis; negative regulation of inflammatory response; negative regulation of multicellular organism growth; negative regulation of ossification; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of apoptosis; positive regulation of ATPase activity; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of MAPKKK cascade; positive regulation of potassium ion transport; positive regulation of protein ubiquitination; positive regulation of skeletal muscle growth; positive regulation of the force of heart contraction by epinephrine; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; receptor-mediated endocytosis; regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; regulation of smooth muscle contraction; regulation of sodium ion transport; regulation of systemic arterial blood pressure by norepinephrine-epinephrine; regulation of vasodilation; response to cold; signal transduction; synaptic transmission, glutamatergic; wound healing
Research Articles on ADRb2
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Product Notes
The ADRb2 adrb2 (Catalog #AAA2126440) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HRP-Linked Polyclonal Antibody to Adrenergic Receptor Beta 2 (ADRb2) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Adrenergic Receptor Beta 2 (ADRb2) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP). WB: 0.5-2ug/mL IHC: 5-20ug/mL ICC: 5-20ug/mL. Researchers should empirically determine the suitability of the ADRb2 adrb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Adrenergic Receptor Beta 2 (ADRb2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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