Rabbit ADMA Polyclonal Antibody | anti-AGXT2 antibody

ADMA (Asymmetric Dimethylarginine)

Cat. Num. AAA619029

• Gene Names: AGXT2; AGT2; DAIBAT
• Reactivity: Using conjugated ADMA-KLH, antibody specificity was performed with an ELISA test by competition experiences with the following compounds:; Compound: Cross-reactivity ration(a); ADMA-BSA: 1; SDMA-BSA: 1:>100; NDMA-BSA: 1:>100; L-Arginine-BSA: 1:>
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: ADMA; Polyclonal Antibody; ADMA (Asymmetric Dimethylarginine); Anti -ADMA (Asymmetric Dimethylarginine); anti-AGXT2 antibody

• Host: Rabbit
• Reactivity: Using conjugated ADMA-KLH, antibody specificity was performed with an ELISA test by competition experiences with the following compounds:; Compound: Cross-reactivity ration(a); ADMA-BSA: 1; SDMA-BSA: 1:>100; NDMA-BSA: 1:>100; L-Arginine-BSA: 1:>
• Clonality: Polyclonal
• Isotype: IgG1
• Specificity: Recognizes ADMA.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from 50mM Tris, pH 7.4. Reconstitute with sterile ddH2O to a concentration of 1mg/ml.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-AGXT2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: ADMA, conjugated to KLH.
• Crossreactivity Notes: (a) ASMA-BSA concentration/unconjugated or conjugated amino acids concentration at half displacement BSA=Bovine Serum Albumin
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-AGXT2 antibody

Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical involved in normal endothelial function and, by extension, cardiovascular health.

Product Categories/Family for anti-AGXT2 antibody

Antibodies; Abs to Amino Acids

NCBI and Uniprot Product Information

• NCBI GI #: 13994255
• NCBI GeneID: 64902
• NCBI Accession #: NP_114106.1
• NCBI GenBank Nucleotide #: NM_031900.3
• UniProt Accession #: Q9BYV1; Q53FB4; Q53FY7; Q53G03; Q5W7Q1
• Molecular Weight: 57,156 Da
• NCBI Official Full Name: alanine--glyoxylate aminotransferase 2, mitochondrial
• NCBI Official Synonym Full Names: alanine--glyoxylate aminotransferase 2
• NCBI Official Symbol: AGXT2
• NCBI Official Synonym Symbols: AGT2; DAIBAT
• NCBI Protein Information: alanine--glyoxylate aminotransferase 2, mitochondrial; beta-ALAAT II; beta-alanine-pyruvate aminotransferase; (R)-3-amino-2-methylpropionate--pyruvate transaminase
• UniProt Protein Name: Alanine--glyoxylate aminotransferase 2, mitochondrial
• Protein Family: Alanine--glyoxylate aminotransferase
• UniProt Gene Name: AGXT2
• UniProt Synonym Gene Names: AGT2; AGT 2
• UniProt Entry Name: AGT2_HUMAN

NCBI Description

The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]

Uniprot Description

AGXT2: is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]

Protein type: EC 2.6.1.44; Transferase; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.40

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: beta-alanine-pyruvate transaminase activity; alanine-glyoxylate transaminase activity; (R)-3-amino-2-methylpropionate-pyruvate transaminase activity; pyridoxal phosphate binding

Biological Process: pyrimidine nucleoside catabolic process; positive regulation of nitric oxide biosynthetic process; glyoxylate catabolic process; pyrimidine base metabolic process; glyoxylate metabolic process; nucleobase, nucleoside and nucleotide metabolic process; glycine biosynthetic process, by transamination of glyoxylate; L-alanine catabolic process, by transamination