Rabbit anti-Human Adiponectin Receptor 1 Polyclonal Antibody | anti-ADIPOR1 antibody
Adiponectin Receptor 1
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. [provided by RefSeq, Jan 2012]
Uniprot Description
Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Ref.8
Subunit structure: May form homomultimer and heteromultimers. Ref.8
Subcellular location: Membrane; Multi-pass membrane protein. Note: Localized to the cell membrane and intracellular organelles. Ref.8
Tissue specificity: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. Ref.1 Ref.8
Domain: The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
Sequence similarities: Belongs to the ADIPOR family.
Sequence caution: The sequence AAD34040.1 differs from that shown. Reason: Frameshift at position 369.
Research Articles on ADIPOR1
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Product Notes
The ADIPOR1 adipor1 (Catalog #AAA395707) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Adiponectin Receptor 1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Adiponectin Receptor 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ADIPOR1 adipor1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Adiponectin Receptor 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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