Rabbit anti-Human Adenosine A3 Receptor Polyclonal Antibody | anti-ADORA3 antibody

Adenosine A3 Receptor (A3R)

Cat. Num. AAA616769

• Gene Names: ADORA3; A3AR; AD026; bA552M11.5; RP11-552M11.7
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography
• Synonyms: Adenosine A3 Receptor; Polyclonal Antibody; Adenosine A3 Receptor (A3R); Anti -Adenosine A3 Receptor (A3R); anti-ADORA3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Adenosine A3 Receptor.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography
• Form/Format: Supplied as a powder lyophilized from a solution containing PBS, 1% BSA, and 0.05% sodium azide. Reconstitute with 100ul sterile PBS.

• Applicable Applications for anti-ADORA3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1-10ug/ml using EC; ELISA: 1:10,000-50,000 using 50-100ng of control peptide/well
• Immunogen: A 15aa sequence corresponding to human A3R gene. This region corresponds to the 3rd extracellular domain. A cysteine has been added at the NH2 terminus for coupling to KLH. Species sequence homology: canine: 85%; mouse: 69%; rat: 46%; sheep: 20%.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-ADORA3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4262078
• NCBI GeneID: 140
• UniProt Accession #: Q6LD47; P33765; Q5QNZ3; Q5QNZ4; Q6P2N6; Q9HBK8
• Molecular Weight: 847 Da
• NCBI Official Full Name: adenosine A3 receptor
• NCBI Official Synonym Full Names: adenosine A3 receptor
• NCBI Official Symbol: ADORA3
• NCBI Official Synonym Symbols: A3AR; AD026; bA552M11.5; RP11-552M11.7
• NCBI Protein Information: adenosine receptor A3; OTTHUMP00000013476; OTTHUMP00000013479; OTTHUMP00000013739; OTTHUMP00000082917
• UniProt Protein Name: Adenosine A3 receptor protein
• Protein Family: Adenosine receptor
• UniProt Gene Name: adenosine A3 receptor
• UniProt Entry Name: Q6LD47_HUMAN

NCBI Description

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: mast cell granule; integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of calcium-mediated signaling; positive regulation of mast cell degranulation; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response