Rabbit anti-Human ADCY8 Polyclonal Antibody | anti-ADCY8 antibody

ADCY8 Antibody

Cat. Num. AAA9412493

• Gene Names: ADCY8; AC8; ADCY3; HBAC1
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ADCY8; Polyclonal Antibody; ADCY8 Antibody; Adenylate cyclase type 8; EC 4.6.1.1; Adenylate cyclase type VIII; ATP pyrophosphate-lyase 8; Adenylyl cyclase 8; anti-ADCY8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ADCY8 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 1251

• Applicable Applications for anti-ADCY8 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Immunohistochemistry: 1:50~1:100; Immunofluorescence: 1:100~1:500
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human ADCY8.
• Target Name: ADCY8
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY8 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of A549 cells, using ADCY8 antibody.)

Related Product Information for anti-ADCY8 antibody

This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence By similarity.Defer N., FEBS Lett. 351:109-113(1994).Parma J., Biochem. Biophys. Res. Commun. 179:455-462(1991).Sjoeblom T., Science 314:268-274(2006).

Product Categories/Family for anti-ADCY8 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4557257
• NCBI GeneID: 114
• NCBI Accession #: NP_001106.1
• NCBI GenBank Nucleotide #: NM_001115.2
• UniProt Accession #: P40145
• Molecular Weight: 140,122 Da
• NCBI Official Full Name: adenylate cyclase type 8
• NCBI Official Synonym Full Names: adenylate cyclase 8 (brain)
• NCBI Official Symbol: ADCY8
• NCBI Official Synonym Symbols: AC8; ADCY3; HBAC1
• NCBI Protein Information: adenylate cyclase type 8
• UniProt Protein Name: Adenylate cyclase type 8
• Protein Family: Adenylate cyclase
• UniProt Gene Name: ADCY8
• UniProt Synonym Gene Names: AC8
• UniProt Entry Name: ADCY8_HUMAN

NCBI Description

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

Uniprot Description

ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, aquaporin family; EC 4.6.1.1; Nucleotide Metabolism - purine; Lyase; Transporter; Adenylyl cyclase

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport