Goat ADAP2 / CENTA2 Polyclonal Antibody | anti-ADAP2 antibody

Goat Polyclonal to Human ADAP2 / CENTA2

Cat. Num. AAA241949

• Gene Names: ADAP2; CENTA2; cent-b; HSA272195
• Reactivity: Human, Monkey
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: ADAP2 / CENTA2; Polyclonal Antibody; Goat Polyclonal to Human ADAP2 / CENTA2; Anti-ADAP2 / CENTA2 Antibody (C-Terminus) IHC-plus; Cent-b; Cnt-a2; CENTA2; Centaurin-alpha-2; Centaurin; alpha 2; Centaurin-alpha 2 protein; HSA272195; ArfGAP with dual PH domains 2; Centaurin beta; Human ADAP2; anti-ADAP2 antibody

• Host: Goat
• Reactivity: Human, Monkey
• Clonality: Polyclonal
• Specificity: Human ADAP2 / CENTA2.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 381

• Applicable Applications for anti-ADAP2 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:32000), IHC-P (5 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-RLTASTESGRSSR from the C-terminus of human ADAP2 / CENTA2 (NP_060874.1). Percent identity by BLAST analysis: Human, Monkey (100%); Gibbon, Bat, Horse (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: ADAP2 / CENTA2 antibody was raised against synthetic peptide C-RLTASTESGRSSR from the C-terminus of human ADAP2 / CENTA2 (NP_060874.1). Percent identity by BLAST analysis: Human, Monkey (100%); Gibbon, Bat, Horse (85%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ADAP2 / CENTA2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 8923763
• NCBI GeneID: 55803
• NCBI Accession #: NP_060874.1
• NCBI GenBank Nucleotide #: NM_018404.2
• UniProt Accession #: Q9NPF8; Q8N4Q6; Q96SD5
• Molecular Weight: 44,221 Da
• NCBI Official Full Name: arf-GAP with dual PH domain-containing protein 2
• NCBI Official Synonym Full Names: ArfGAP with dual PH domains 2
• NCBI Official Symbol: ADAP2
• NCBI Official Synonym Symbols: CENTA2; cent-b; HSA272195
• NCBI Protein Information: arf-GAP with dual PH domain-containing protein 2; cnt-a2; centaurin beta; centaurin-alpha-2; centaurin, alpha 2; centaurin-alpha 2 protein
• UniProt Protein Name: Arf-GAP with dual PH domain-containing protein 2
• Protein Family: Arf-GAP with dual PH domain-containing protein
• UniProt Gene Name: ADAP2
• UniProt Synonym Gene Names: CENTA2; Cnt-a2
• UniProt Entry Name: ADAP2_HUMAN

Uniprot Description

CENTA2: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, ARF; Lipid-binding; GAPs; Mitochondrial

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: mitochondrial envelope; cytoplasm; plasma membrane

Molecular Function: protein binding, bridging; protein binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; inositol 1,3,4,5 tetrakisphosphate binding; zinc ion binding; phosphatidylinositol-3,4-bisphosphate binding

Biological Process: heart development; positive regulation of GTPase activity