Rabbit ADAMTSL4 Polyclonal Antibody | anti-ADAMTSL4 antibody

ADAMTSL4 Rabbit Polyclonal

Cat. Num. AAA766379

• Gene Names: ADAMTSL4; TSRC1; ECTOL2; ADAMTSL-4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ADAMTSL4; Polyclonal Antibody; ADAMTSL4 Rabbit Polyclonal; anti-ADAMTSL4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1097

• Applicable Applications for anti-ADAMTSL4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: ADAMTS-like 4
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using MBS766379 (ADAMTSL4 Antibody) at dilution of 1:50)

Testing Data

()

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS766379 (ADAMTSL4 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 568384853
• NCBI GeneID: 54507
• NCBI Accession #: NP_001275537.1
• NCBI GenBank Nucleotide #: NM_001288608.1
• Molecular Weight: 118,822 Da
• NCBI Official Full Name: ADAMTS-like protein 4 isoform 4
• NCBI Official Synonym Full Names: ADAMTS like 4
• NCBI Official Symbol: ADAMTSL4
• NCBI Official Synonym Symbols: TSRC1; ECTOL2; ADAMTSL-4
• NCBI Protein Information: ADAMTS-like protein 4
• UniProt Protein Name: ADAMTS-like protein 4
• Protein Family: ADAMTS-like protein
• UniProt Gene Name: ADAMTSL4
• UniProt Synonym Gene Names: ADAMTSL-4
• UniProt Entry Name: ATL4_HUMAN

NCBI Description

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]

Uniprot Description

TSRC1: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Defects in ADAMTSL4 are a cause of autosomal recessive isolated ectopia lentis (ARI-EL). ARI-EL is a rare condition characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: endoplasmic reticulum lumen

Molecular Function: metalloendopeptidase activity; protease binding; protein binding

Biological Process: apoptosis; extracellular matrix organization and biogenesis; positive regulation of apoptosis; proteolysis

Disease: Ectopia Lentis 2, Isolated, Autosomal Recessive; Ectopia Lentis Et Pupillae