Rabbit anti-Human ADAMTS17 Polyclonal Antibody | anti-ADAMTS17 antibody

ADAMTS17 Antibody (Center)

Cat. Num. AAA9216239

• Reactivity: Human
• Applications: Western Blot
• Synonyms: ADAMTS17; Polyclonal Antibody; ADAMTS17 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM-TS 17; ADAM-TS17; ADAMTS-17; 3424-; anti-ADAMTS17 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This ADAMTS17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 508-540 amino acids from the Central region of human ADAMTS17.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 1095

• Applicable Applications for anti-ADAMTS17 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-ADAMTS17 Antibody (Center) at 1:2000 dilutionLane 1: A431 whole cell lysatesLane 2: A2058 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 121 kDa.Blocking/Dilution buffer: 5% NFDM/TBST.)

Product Categories/Family for anti-ADAMTS17 antibody

Cell Biology; Signal transduction

References

Cal S.,et al.Gene 283:49-62(2002). Tan J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004). Zody M.C.,et al.Nature 440:671-675(2006). Morales J.,et al.Am. J. Hum. Genet. 85:558-568(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 110611170
• NCBI GeneID: 170691
• NCBI Accession #: NP_620688.2
• NCBI GenBank Nucleotide #: NM_139057.2
• UniProt Accession #: Q8TE56; Q2I7G4; Q6ZN75
• Molecular Weight: 121127
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 17 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif 17
• NCBI Official Symbol: ADAMTS17
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 17
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 17
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: ADAMTS17
• UniProt Synonym Gene Names: ADAM-TS 17; ADAM-TS17; ADAMTS-17
• UniProt Entry Name: ATS17_HUMAN

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: proteinaceous extracellular matrix

Molecular Function: zinc ion binding; metalloendopeptidase activity

Biological Process: proteolysis

Disease: Weill-marchesani-like Syndrome