Western Blot (WB)
(Anti-ADAMTS1 antibody, MBS176276, Western blottingAll lanes: Anti ADAMTS1 (MBS176276) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Heart Tissue Lysate at 50ugLane 3: Rat Brain Tissue Lysate at 50ugPredicted bind size: 105KDObserved bind size: 105KD)
Rabbit anti-Mouse, Rat ADAMTS1 Polyclonal Antibody | anti-ADAMTS1 antibody
Anti-ADAMTS1 antibody
Gene Names
Adamts1; C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1
Reactivity
Mouse, Rat
Applications
Western Blot
Purity
Immunogen affinity purified.
Synonyms
ADAMTS1; Polyclonal Antibody; Anti-ADAMTS1 antibody; A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM metallopeptidase with thrombospondin type 1 motif; 1; A disintegrin and metalloproteinase with thrombospondin motifs 1 antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 1 antibody; A disintegrin-like and metalloprotease(reprolysin type) with thrombospondin type 1 motif 1 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 1 antibody; ADAM TS 1 antibody; ADAM TS1 antibody; ADAM-TS 1 antibody; ADAM-TS1 antibody; ADAMTS 1 antibody; ADAMTS antibody; ADAMTS-1 antibody; Adamts1 antibody; ATS1_HUMAN antibody; C3 C5 antibody; KIAA1346 antibody; KIAA1346; antibody; METH 1 antibody; METH-1 antibody; METH1 antibody; anti-ADAMTS1 antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
968
Applicable Applications for anti-ADAMTS1 antibody
Western Blot (WB)
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse ADAMTS1 (956-968aa KHYIDFCTLTQCS), different from the related rat sequence by one amino acid, and from the related human sequence by four amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti-ADAMTS1 antibody, MBS176276, Western blottingAll lanes: Anti ADAMTS1 (MBS176276) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Heart Tissue Lysate at 50ugLane 3: Rat Brain Tissue Lysate at 50ugPredicted bind size: 105KDObserved bind size: 105KD)
Western Blot (WB)
(Anti-ADAMTS1 antibody, MBS176276, Western blottingAll lanes: Anti ADAMTS1 (MBS176276) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Heart Tissue Lysate at 50ugLane 3: Rat Brain Tissue Lysate at 50ugPredicted bind size: 105KDObserved bind size: 105KD)
Related Product Information for anti-ADAMTS1 antibody
Description: Rabbit IgG polyclonal antibody for A disintegrin and metalloproteinase with thrombospondin motifs 1(ADAMTS1) detection. Tested with WB in Mouse, Rat.
Background: ADAMTS1(A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1), also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix(ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. Scott(2000) mapped the ADAMTS1 gene to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. Kuno et al.(1997) found that mouse Adamts1 expression could be induced in vitro in colon adenocarcinoma cells by stimulation with the inflammatory cytokine interleukin 1-alpha, or in vivo in kidney and heart by intravenous administration of lipopolysaccharide. Vazquez et al.(1999) determined that ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.
Background: ADAMTS1(A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1), also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix(ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. Scott(2000) mapped the ADAMTS1 gene to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. Kuno et al.(1997) found that mouse Adamts1 expression could be induced in vitro in colon adenocarcinoma cells by stimulation with the inflammatory cytokine interleukin 1-alpha, or in vivo in kidney and heart by intravenous administration of lipopolysaccharide. Vazquez et al.(1999) determined that ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
105,801 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 1
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
NCBI Official Symbol
Adamts1
NCBI Official Synonym Symbols
C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Gene Name
Adamts1
UniProt Synonym Gene Names
ADAM-TS 1; ADAM-TS1; ADAMTS-1
UniProt Entry Name
ATS1_MOUSE
Uniprot Description
ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.24.-; Motility/polarity/chemotaxis
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; cytoplasm; extracellular region; basement membrane; cytoplasmic vesicle
Molecular Function: peptidase activity; heparin binding; protein binding; zinc ion binding; metallopeptidase activity; hydrolase activity; metal ion binding; metalloendopeptidase activity
Biological Process: negative regulation of angiogenesis; proteolysis; ovulation from ovarian follicle; kidney development
Research Articles on ADAMTS1
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Product Notes
The ADAMTS1 adamts1 (Catalog #AAA176276) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ADAMTS1 antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ADAMTS1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ADAMTS1 adamts1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADAMTS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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