Rabbit anti-Human ADAM23 Polyclonal Antibody | anti-ADAM23 antibody

ADAM23, CT (ADAM23, MDC3, Disintegrin and metalloproteinase domain-containing protein 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (Azide free) (HRP)

Cat. Num. AAA6271523

• Gene Names: ADAM23; MDC3; MDC-3
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ADAM23; Polyclonal Antibody; CT (ADAM23; MDC3; Disintegrin and metalloproteinase domain-containing protein 23; Metalloproteinase-like; disintegrin-like; and cysteine-rich protein 3) (Azide free) (HRP); and cysteine-rich protein 3; anti-ADAM23 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-ADAM23 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ADAM23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 802-831 amino acids from the C-terminal region of human ADAM23.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ADAM23 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ADAM23 antibody detected the ADAM23 protein (arrow).)

Related Product Information for anti-ADAM23 antibody

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.

Product Categories/Family for anti-ADAM23 antibody

Antibodies; Matrix Metalloproteinases

References

Pan, Q., et al. Biochem. Biophys. Res. Commun. 401(2):306-312(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Ferreira, M.A., et al. Allergy 64(11):1623-1628(2009). Costa, M.D., et al. Neurosci. Lett. 461(1):16-20(2009). Verbisck, N.V., et al. Cancer Res. 69(13):5546-5552(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4501913
• NCBI GeneID: 8745
• NCBI Accession #: NP_003803.1
• NCBI GenBank Nucleotide #: NM_003812.3
• UniProt Accession #: O75077; A2RU59
• Molecular Weight: 92,130 Da
• NCBI Official Full Name: disintegrin and metalloproteinase domain-containing protein 23 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 23
• NCBI Official Symbol: ADAM23
• NCBI Official Synonym Symbols: MDC3; MDC-3
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 23
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 23
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: ADAM23
• UniProt Synonym Gene Names: MDC3; ADAM 23; MDC-3
• UniProt Entry Name: ADA23_HUMAN

NCBI Description

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]