Rabbit ACVR1C Polyclonal Antibody | anti-ACVR1C antibody

ACVR1C Polyclonal Antibody

Cat. Num. AAA127029

• Gene Names: ACVR1C; ALK7; ACVRLK7
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: ACVR1C; Polyclonal Antibody; ACVR1C Polyclonal Antibody; ACVRLK7; ALK7; anti-ACVR1C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Sequence Length: 493

• Applicable Applications for anti-ACVR1C antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500 - 1:2000; IHC: 1:10 - 1:200
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-113 of human ACVR1C (NP_660302.2).
• Preparation and Storage: Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of SH-SY5Y cells, using ACVR1C antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat brain using ACVR1C antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using ACVR1C antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse lung using ACVR1C antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse brain using ACVR1C antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse kidney using ACVR1C antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse stomach using ACVR1C antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-ACVR1C antibody

ACVR1C is a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. (Bondestam et al., 2001[PubMed 12063393]).

Product Categories/Family for anti-ACVR1C antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 74762565
• NCBI GeneID: 130399
• UniProt Accession #: Q8NER5; Q4ZFZ8; Q86UL1; Q86UL2; Q8TBG2
• Molecular Weight: Calculated MW: 37kDa/46kDa/49kDa/54kDa; Observed MW: 60kDa
• NCBI Official Full Name: Activin receptor type-1C
• NCBI Official Synonym Full Names: activin A receptor, type IC
• NCBI Official Symbol: ACVR1C
• NCBI Official Synonym Symbols: ALK7; ACVRLK7
• NCBI Protein Information: activin receptor type-1C; ALK-7; ACVR1C; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7
• UniProt Protein Name: Activin receptor type-1C
• Protein Family: Activin receptor
• UniProt Gene Name: ACVR1C
• UniProt Synonym Gene Names: ACTR-IC; ALK-7
• UniProt Entry Name: ACV1C_HUMAN

NCBI Description

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Uniprot Description

ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q24.1

Cellular Component: plasma membrane; activin receptor complex

Molecular Function: transforming growth factor beta receptor activity; activin receptor activity, type I; metal ion binding; growth factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; negative regulation of insulin secretion; response to insulin stimulus