Rabbit anti-Human ACTL7B Polyclonal Antibody | anti-ACTL7B antibody

ACTL7B Antibody (N-term)

Cat. Num. AAA9206699

• Gene Names: ACTL7B; Tact1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: ACTL7B; Polyclonal Antibody; ACTL7B Antibody (N-term); Actin-like protein 7B; Actin-like-7-beta; anti-ACTL7B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This ACTL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the N-terminal region of human ACTL7B.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.46 (varies by lot)
• Sequence Positions: 69-97
• Sequence Length: 415

• Applicable Applications for anti-ACTL7B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(ACTL7B Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ACTL7B antibody detected the ACTL7B protein (arrow).)

Related Product Information for anti-ACTL7B antibody

The protein encoded by this gene is a member of a family
of actin-related proteins (ARPs) which share significant amino acid
sequence identity to conventional actins. Both actins and ARPs have
an actin fold, which is an ATP-binding cleft, as a common feature.
The ARPs are involved in diverse cellular processes, including
vesicular transport, spindle orientation, nuclear migration and
chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A,
are intronless, and are located approximately 4 kb apart in a
head-to-head orientation within the familial dysautonomia candidate
region on 9q31. Based on mutational analysis of the ACTL7B gene in
patients with this disorder, it was concluded that it is unlikely
to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A,
the ACTL7B gene is expressed predominantly in the testis, however,
its exact function is not known.

Product Categories/Family for anti-ACTL7B antibody

Signal Transduction

References

Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Hisano, M., et al. Nucleic Acids Res. 31(16):4797-4804(2003)
Chadwick, B.P., et al. Genomics 58(3):302-309(1999)
Schafer, D.A., et al. Annu. Rev. Cell Dev. Biol. 15, 341-363 (1999) :

NCBI and Uniprot Product Information

• NCBI GI #: 5729722
• NCBI GeneID: 10880
• NCBI Accession #: NP_006677.1
• NCBI GenBank Nucleotide #: NM_006686.3
• UniProt Accession #: Q9Y614; Q5JSV1; B2R9Q2
• Molecular Weight: 45234
• NCBI Official Full Name: actin-like protein 7B
• NCBI Official Synonym Full Names: actin-like 7B
• NCBI Official Symbol: ACTL7B
• NCBI Official Synonym Symbols: Tact1
• NCBI Protein Information: actin-like protein 7B
• UniProt Protein Name: Actin-like protein 7B
• Protein Family: Actin-like protein
• UniProt Gene Name: ACTL7B
• UniProt Entry Name: ACL7B_HUMAN

NCBI Description

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]

Uniprot Description

ACTL7B: is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: cytoplasm; actin cytoskeleton

Molecular Function: structural constituent of cytoskeleton