Western Blot (WB)
(All lanes: Activin receptor type-2A antibody at 3ug/ml+mouse brain tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 58,46 kDaObserved band size: 58 kDa)
Rabbit anti-Human, Mouse Activin receptor type-2A Polyclonal Antibody | anti-ACVR2A antibody
Rabbit anti-human Activin receptor type-2A polyclonal Antibody(ACVR2A)
IHC:1:20-1:200
Western Blot (WB)
(All lanes: Activin receptor type-2A antibody at 3ug/ml+mouse brain tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 58,46 kDaObserved band size: 58 kDa)
Western Blot (WB)
(All lanes: Activin receptor type-2A antibody at 3ug/ml+mouse brain tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 58,46 kDaObserved band size: 58 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin using MBS1497574 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin using MBS1497574 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver cancer using MBS1497574 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver cancer using MBS1497574 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Uniprot Description
ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.
Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Protein kinase, TKL; Membrane protein, integral; Motility/polarity/chemotaxis; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 2q22.3
Cellular Component: cell surface; cytoplasm; integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: activin binding; activin receptor activity; ATP binding; coreceptor activity; growth factor binding; metal ion binding; PDZ domain binding; protein binding; protein self-association; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; BMP signaling pathway; determination of left/right symmetry; embryonic skeletal development; gastrulation with mouth forming second; mesoderm development; penile erection; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of erythrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of BMP signaling pathway; regulation of nitric-oxide synthase activity; Sertoli cell proliferation; sperm ejaculation; spermatogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway
Research Articles on ACVR2A
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Product Notes
The ACVR2A acvr2a (Catalog #AAA1497574) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Activin receptor type-2A polyclonal Antibody(ACVR2A) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Activin receptor type-2A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Recommended dilution: WB:1:200-1000 IHC:1:20-1:200. Researchers should empirically determine the suitability of the ACVR2A acvr2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Activin receptor type-2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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