Goat Acrosin heavy chain Polyclonal Antibody | anti-ACR antibody
Goat anti-Acrosin heavy chain Antibody
Western Blot: Preliminary experiments in Human Testis lysates gave no specific signal but low background (at antibody concentration up to 2ug/ml).
NCBI and Uniprot Product Information
NCBI Description
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
Uniprot Description
ACR: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.10; Protease
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: acrosomal matrix; extracellular region; Golgi-associated vesicle; nucleus; protein complex
Molecular Function: amidase activity; copper ion binding; DNA binding; drug binding; fucose binding; mannose binding; protease binding; protein binding; serine-type endopeptidase activity; zinc ion binding
Biological Process: acrosome matrix dispersal; acrosome reaction; adenylate cyclase activation; binding of sperm to zona pellucida; penetration of zona pellucida; response to steroid hormone stimulus; single fertilization
Research Articles on ACR
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Product Notes
The ACR acr (Catalog #AAA423391) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Acrosin heavy chain Antibody reacts with Expected from sequence similarity: Human, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's Acrosin heavy chain can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Preliminary experiments in Human Testis lysates gave no specific signal but low background (at antibody concentration up to 2ug/ml). Researchers should empirically determine the suitability of the ACR acr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HEKYNSATEG ND. It is sometimes possible for the material contained within the vial of "Acrosin heavy chain, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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