Western Blot (WB)
(Western blot (WB) analysis of Acinus (Phospho-S1180) polyclonal antibody at 1:500 dilutionLaneA: A549 whole cell lysateLaneB: Hela whole cell lysateLaneC: Jurkat whole cell lysateLaneD: NIH3T3 whole cell lysateLaneE: H9C2 whole cell lysateLaneF: PC12 whole cell lysate)
Rabbit Acinus Polyclonal Antibody | anti-ACIN1 antibody
Acinus (Phospho-S1180) polyclonal antibody
IHC: 1:50~1:200
Western Blot (WB)
(Western blot (WB) analysis of Acinus (Phospho-S1180) polyclonal antibody at 1:500 dilutionLaneA: A549 whole cell lysateLaneB: Hela whole cell lysateLaneC: Jurkat whole cell lysateLaneD: NIH3T3 whole cell lysateLaneE: H9C2 whole cell lysateLaneF: PC12 whole cell lysate)
Western Blot (WB)
(Western blot (WB) analysis of Acinus (Phospho-S1180) polyclonal antibody at 1:500 dilutionLaneA: A549 whole cell lysateLaneB: Hela whole cell lysateLaneC: Jurkat whole cell lysateLaneD: NIH3T3 whole cell lysateLaneE: H9C2 whole cell lysateLaneF: PC12 whole cell lysate)
NCBI and Uniprot Product Information
NCBI Description
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
acinus: an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described.
Protein type: RNA-binding; RNA splicing; Spliceosome; Apoptosis
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: nucleoplasm; cytoplasm; nucleolus; plasma membrane; nuclear speck; cytosol; nucleus
Molecular Function: protein binding; enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding
Biological Process: positive regulation of monocyte differentiation; negative regulation of nuclear mRNA splicing, via spliceosome; apoptosis; positive regulation of apoptosis; RNA splicing; erythrocyte differentiation; mRNA processing; apoptotic chromosome condensation; cell structure disassembly during apoptosis
Research Articles on ACIN1
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Product Notes
The ACIN1 acin1 (Catalog #AAA3015078) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Acinus (Phospho-S1180) polyclonal antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Acinus can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500~1:1000 IHC: 1:50~1:200. Researchers should empirically determine the suitability of the ACIN1 acin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Acinus, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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