Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS766310 (ACD Antibody) at dilution of 1:1500)
Rabbit anti-Human ACD Polyclonal Antibody | anti-ACD antibody
ACD Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS766310 (ACD Antibody) at dilution of 1:1500)
Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS766310 (ACD Antibody) at dilution of 1:1500)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]
Uniprot Description
ACD: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus
Molecular Function: protein binding; telomeric DNA binding
Biological Process: embryonic limb morphogenesis; intracellular protein transport; negative regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; segmentation; skeletal development; telomere assembly; telomere capping; telomere maintenance; telomere maintenance via telomerase; urogenital system development
Disease: Dyskeratosis Congenita, Autosomal Dominant 6
Research Articles on ACD
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Product Notes
The ACD acd (Catalog #AAA766310) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ACD Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ACD can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the ACD acd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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