Rabbit ACBP Polyclonal Antibody | anti-ACBP antibody

ACBP Polyclonal Antibody

Cat. Num. AAA9412676

• Gene Names: DBI; EP; ACBP; ACBD1; CCK-RP
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ACBP; Polyclonal Antibody; ACBP Polyclonal Antibody; DBI; Acyl-CoA-binding protein; Diazepam-binding inhibitor; Endozepine; EP; anti-ACBP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: ACBP Polyclonal Antibody detects endogenous levels of ACBP protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 87

• Applicable Applications for anti-ACBP antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Western Blot: 1:500 - 1:2000; ELISA: 1:20000; ; Not yet tested in other applications.
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from the C-terminal region of human ACBP.
• Target Name: ACBP
• Preparation and Storage: Store at -20°C/1 year

Western Blot (WB)

(Western Blot analysis of MCF7 U251 mouse liver mouse kidney cells using ACBP Polyclonal Antibody)

Product Categories/Family for anti-ACBP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 120433590
• NCBI GeneID: 1622
• NCBI Accession #: NP_001073331.1
• NCBI GenBank Nucleotide #: NM_001079862.2
• UniProt Accession #: P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8; B8ZWD2; B8ZWD6; B8ZWD7
• Molecular Weight: SDS-PAGE MW: 10kd
• NCBI Official Full Name: acyl-CoA-binding protein isoform 3
• NCBI Official Synonym Full Names: diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
• NCBI Official Symbol: DBI
• NCBI Official Synonym Symbols: EP; ACBP; ACBD1; CCK-RP
• NCBI Protein Information: acyl-CoA-binding protein
• UniProt Protein Name: Acyl-CoA-binding protein
• UniProt Gene Name: DBI
• UniProt Synonym Gene Names: ACBP; DBI; EP
• UniProt Entry Name: ACBP_HUMAN

NCBI Description

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.