Rabbit anti-Mouse ABCG3 Polyclonal Antibody | anti-Abcg3 antibody

ABCG3 (ATP-binding Cassette (ABC) Transporter 3)

Cat. Num. AAA615213

• Gene Names: Abcg3; Mxr2; Abcp2
• Reactivity: Mouse
• Applications: ELISA
• Purity: Purified by immunoaffinity chromatography.
• Synonyms: ABCG3; Polyclonal Antibody; ABCG3 (ATP-binding Cassette (ABC) Transporter 3); Anti -ABCG3 (ATP-binding Cassette (ABC) Transporter 3); anti-Abcg3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse ABCG3.
• Purity/Purification: Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, 0.1% BSA. Reconstitute with 100ul sterile PBS.
• Concentration: ~1mg/mL (after reconstitution) (varies by lot)

• Applicable Applications for anti-Abcg3 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA. Other potential application, though not tested is Western Blot. Other applications not tested.; ; ELISA: 0.5-1ug/ml; Use control peptide (Cat #A0004-04U1) to coat ELISA plates at 1ug/ml.; Optimal dilutions to be deermined by the researcher.
• Immunogen: Synthetic peptide corresponding to 14aa near the C terminal, extracellular domain of mouse ABCG3, conjugated to KLH. Species Sequence Homology: rat, 100%.
• Grade: Affinity Purified
• Preparation and Storage: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Abcg3 antibody

The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes, host-defense mechanism to xenobiotics. The first known members were P-glycoprotein (P-gp) and multidrug resistant protein (MRP), cause multidrug resistance when transfected into drug-sensitive cells. In addition, increasing numbers of ABC proteins have recently been identified. ABCG3 protein is a 650aa protein in mouse, highly expressed in the thymus and spleen. It seems to have defective ATP binding region, which suggests the ABCG3 protein may not bind or hydrolyze ATP. Therefore, it has to dimerize with another subunit to form a functional transporter. It is unique among ABC genes in not having several highly conserved residues in the A and C domains of NBF. ABCG3 is the most closely related to ABCG2 with 54% homology overall, 64% in the NBF and 50% in the TM region.

Product Categories/Family for anti-Abcg3 antibody

Antibodies; Abs to Multi Drug Resistance (MDR)

NCBI and Uniprot Product Information

• NCBI GI #: 66932959
• NCBI GeneID: 27405
• NCBI Accession #: NP_084515.2
• NCBI GenBank Nucleotide #: NM_030239.2
• UniProt Accession #: Q8BKI5; Q99P81
• NCBI Official Full Name: ATP-binding cassette sub-family G member 3
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family G (WHITE), member 3
• NCBI Official Symbol: Abcg3
• NCBI Official Synonym Symbols: Mxr2; Abcp2
• NCBI Protein Information: ATP-binding cassette sub-family G member 3; OTTMUSP00000031098; OTTMUSP00000031125; ATP-binding cassette, subfamily G, member 3
• UniProt Protein Name: ATP-binding cassette sub-family G member 3
• Protein Family: ABC transporter G family
• UniProt Gene Name: Abcg3
• UniProt Entry Name: ABCG3_MOUSE

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq]

Uniprot Description

ABCG3: is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]

Protein type: Transporter; Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: ATPase activity; ATP binding

Biological Process: transport