Rabbit ABCD2 Polyclonal Antibody | anti-ABCD2 antibody

ABCD2 Rabbit Polyclonal

Cat. Num. AAA766270

• Gene Names: ABCD2; ALDR; ABC39; ALDL1; ALDRP; hALDR
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ABCD2; Polyclonal Antibody; ABCD2 Rabbit Polyclonal; anti-ABCD2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 740

• Applicable Applications for anti-ABCD2 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: ATP-binding cassette, sub-family D (ALD), member 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Testing Data

()

Western Blot (WB)

(mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with MBS766270 (ABCD2 Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 9945308
• NCBI GeneID: 225
• NCBI Accession #: NP_005155.1
• NCBI GenBank Nucleotide #: NM_005164.3
• Molecular Weight: 83,233 Da
• NCBI Official Full Name: ATP-binding cassette sub-family D member 2
• NCBI Official Synonym Full Names: ATP binding cassette subfamily D member 2
• NCBI Official Symbol: ABCD2
• NCBI Official Synonym Symbols: ALDR; ABC39; ALDL1; ALDRP; hALDR
• NCBI Protein Information: ATP-binding cassette sub-family D member 2
• UniProt Protein Name: ATP-binding cassette sub-family D member 2
• Protein Family: ABC transporter D family
• UniProt Gene Name: ABCD2
• UniProt Synonym Gene Names: ALD1; ALDL1; ALDR; ALDRP; hALDR
• UniProt Entry Name: ABCD2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, ABC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytosol; integral to membrane; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; long-chain fatty acid transporter activity; protein binding; protein homodimerization activity

Biological Process: fatty acid beta-oxidation; long-chain fatty acid transport; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process