Rabbit ABCC9 Polyclonal Antibody | anti-ABCC9 antibody

ABCC9 Antibody

Cat. Num. AAA9405995

• Gene Names: ABCC9; SUR2; ABC37; CANTU; CMD1O; ATFB12
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: ABCC9; Polyclonal Antibody; ABCC9 Antibody; SUR2; ABC37; CANTU; CMD1O; ATFB12; anti-ABCC9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ABCC9 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.8 mg/ml (varies by lot)
• Sequence Length: 1549

• Applicable Applications for anti-ABCC9 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:200-1:1000; Immunohistochemistry: 1:40-1:150
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human ATP-binding cassette, sub-family C (CFTR/MRP), member 9
• Target Name: ABCC9
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 6%SDS-PAGE Lysate: 40ug Mouse bladder tissuePrimary antibody: 1/300 dilution Secondary antibody dilution: 1/8000Exposure time: 5 minutes)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/35.)

Related Product Information for anti-ABCC9 antibody

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle.

Product Categories/Family for anti-ABCC9 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 110832835
• NCBI GeneID: 10060
• NCBI Accession #: NP_005682.2
• NCBI GenBank Nucleotide #: NM_005691.3
• UniProt Accession #: O60706; O60707
• Molecular Weight: 174,425 Da
• NCBI Official Full Name: ATP-binding cassette sub-family C member 9 isoform SUR2A
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
• NCBI Official Symbol: ABCC9
• NCBI Official Synonym Symbols: SUR2; ABC37; CANTU; CMD1O; ATFB12
• NCBI Protein Information: ATP-binding cassette sub-family C member 9
• UniProt Protein Name: ATP-binding cassette sub-family C member 9
• Protein Family: ABC transporter C family
• UniProt Gene Name: ABCC9
• UniProt Synonym Gene Names: SUR2
• UniProt Entry Name: ABCC9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Uniprot Description

ABCC9: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O); also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12). ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Defects in ABCC9 are the cause of hypertrichotic osteochondrodysplasia (HTOCD). A rare disorder characterized by congenital hypertrichosis, neonatal macrosomia, a distinct osteochondrodysplasia, and cardiomegaly. The hypertrichosis leads to thick scalp hair, which extends onto the forehead, and a general increase in body hair. In addition, macrocephaly and coarse facial features, including a broad nasal bridge, epicanthal folds, a wide mouth, and full lips, can be suggestive of a storage disorder. About half of affected individuals are macrosomic and edematous at birth, whereas in childhood they usually have a muscular appearance with little subcutaneous fat. Thickened calvarium, narrow thorax, wide ribs, flattened or ovoid vertebral bodies, coxa valga, osteopenia, enlarged medullary canals, and metaphyseal widening of long bones have been reported. Cardiac manifestations such as patent ductus arteriosus, ventricular hypertrophy, pulmonary hypertension, and pericardial effusions are present in approximately 80% of cases. Motor development is usually delayed due to hypotonia. Most patients have a mild speech delay, and a small percentage have learning difficulties or intellectual disability. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ABC family

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: voltage-gated potassium channel complex; sarcomere; plasma membrane; ATP-sensitive potassium channel complex; sarcolemma

Molecular Function: potassium channel regulator activity; potassium channel activity; sulfonylurea receptor activity; transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding

Biological Process: synaptic transmission; potassium ion import; metabolic process; signal transduction; transmembrane transport; defense response to virus; potassium ion transport

Disease: Cantu Syndrome; Cardiomyopathy, Dilated, 1o; Atrial Fibrillation, Familial, 12