Rabbit anti-Human ABCC11 Polyclonal Antibody | anti-ABCC11 antibody

ABCC11, NT (ABCC11, MRP8, ATP-binding cassette sub-family C member 11, Multidrug resistance-associated protein 8) (MaxLight 750)

Cat. Num. AAA6270428

• Gene Names: ABCC11; WW; EWWD; MRP8
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ABCC11; Polyclonal Antibody; NT (ABCC11; MRP8; ATP-binding cassette sub-family C member 11; Multidrug resistance-associated protein 8) (MaxLight 750); Multidrug resistance-associated protein 8; anti-ABCC11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-ABCC11 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:50-100; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: ABCC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350~380 amino acids from the N-terminal region of human ABCC11.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-ABCC11 antibody

ABCC11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1.

Product Categories/Family for anti-ABCC11 antibody

Antibodies; Multi Drug Resistance (MDR)

References

Martin, A., et al. J. Invest. Dermatol. 130(2):529-540(2010). J. Hum. Genet. 54(9):499-503(2009). Sato, T., et al. J. Hum. Genet. 54(7):409-413(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 21729873
• NCBI GeneID: 85320
• NCBI Accession #: NP_115972.2; NP_660187.1
• NCBI GenBank Nucleotide #: NM_032583.3
• UniProt Accession #: Q96J66; Q8TDJ0; Q96JA6; Q9BX80
• Molecular Weight: 150,093 Da
• NCBI Official Full Name: ATP-binding cassette sub-family C member 11 isoform a
• NCBI Official Synonym Full Names: ATP binding cassette subfamily C member 11
• NCBI Official Symbol: ABCC11
• NCBI Official Synonym Symbols: WW; EWWD; MRP8
• NCBI Protein Information: ATP-binding cassette sub-family C member 11
• UniProt Protein Name: ATP-binding cassette sub-family C member 11
• Protein Family: ABC transporter C family
• UniProt Gene Name: ABCC11
• UniProt Synonym Gene Names: MRP8

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E217betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.