Rabbit anti-Human, Mouse ABCA4 Polyclonal Antibody | anti-ABCA4 antibody

ABCA4 Polyclonal Antibody

Cat. Num. AAA8530563

• Gene Names: ABCA4; FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ABCA4; Polyclonal Antibody; ABCA4 Polyclonal Antibody; Retinal-specific ATP-binding cassette transporter; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Stargardt disease protein; ABCR; anti-ABCA4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
• Sequence Length: 2273

• Applicable Applications for anti-ABCA4 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-2000; ELISA: 1:5000-20000
• Immunogen: Synthesized peptide derived from human protein. at AA range: 630-710
• Preparation and Storage: Store at-20 degree C for 1 year.

NCBI and Uniprot Product Information

• NCBI GI #: 105990541
• NCBI GeneID: 24
• NCBI Accession #: NP_000341.2
• NCBI GenBank Nucleotide #: NM_000350.2
• UniProt Accession #: P78363; O15112; O60438; O60915; Q0QD48; Q4LE31
• Molecular Weight: 250
• NCBI Official Full Name: retinal-specific ATP-binding cassette transporter
• NCBI Official Synonym Full Names: ATP binding cassette subfamily A member 4
• NCBI Official Symbol: ABCA4
• NCBI Official Synonym Symbols: FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1
• NCBI Protein Information: retinal-specific ATP-binding cassette transporter
• UniProt Protein Name: Retinal-specific ATP-binding cassette transporter
• Protein Family: ABC transporter A family
• UniProt Gene Name: ABCA4
• UniProt Synonym Gene Names: ABCR; RIM protein; RmP

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]

Uniprot Description

In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.