Rabbit anti-Human, mouse ABCA1 Polyclonal Antibody | anti-ABCA1 antibody

ABCA1 Antibody

Cat. Num. AAA416311

• Gene Names: ABCA1; TGD; ABC1; CERP; ABC-1; HDLDT1
• Reactivity: Human, mouse
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: ABCA1; Polyclonal Antibody; ABCA1 Antibody; anti-ABCA1 antibody

• Host: Rabbit
• Reactivity: Human, mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This Polyclonal antibody is directed against human ABCA1 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human ABCA1. Cross-reactivity with ABCA1 from other sources has not been determined.
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 2261

• Applicable Applications for anti-ABCA1 antibody: Western Blot (WB)
• Immunogen: Synthetic peptide derived from Human ABCA1.
• Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

Related Product Information for anti-ABCA1 antibody

ABCA1 is a Rabbit polyclonal to ABCA1

NCBI and Uniprot Product Information

• NCBI GI #: 21536376
• NCBI GeneID: 19
• NCBI Accession #: NP_005493.2
• NCBI GenBank Nucleotide #: NM_005502.3
• UniProt Accession #: O95477; Q5VX33; Q96S56; Q96T85; Q9NQV4; Q9UN06; Q9UN07; Q9UN08; Q9UN09
• Molecular Weight: 254,302 Da
• NCBI Official Full Name: ATP-binding cassette sub-family A member 1
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family A (ABC1), member 1
• NCBI Official Symbol: ABCA1
• NCBI Official Synonym Symbols: TGD; ABC1; CERP; ABC-1; HDLDT1
• NCBI Protein Information: ATP-binding cassette sub-family A member 1; membrane-bound; ATP-binding cassette transporter A1; cholesterol efflux regulatory protein
• UniProt Protein Name: ATP-binding cassette sub-family A member 1
• Protein Family: ABC transporter A family
• UniProt Gene Name: ABCA1
• UniProt Synonym Gene Names: ABC1; CERP; ABC-1
• UniProt Entry Name: ABCA1_HUMAN

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.

Subunit structure: Interacts with MEGF10. Ref.11

Subcellular location: Membrane; Multi-pass membrane protein Ref.13 Ref.14.

Tissue specificity: Widely expressed, but most abundant in macrophages.

Induction: By bacterial lipopolysaccharides (LPS). LPS regulates expression through a liver X receptor (LXR) -independent mechanism. Repressed by ZNF202. Ref.10

Domain: Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Post-translational modification: Phosphorylation on Ser-2054 regulates phospholipid efflux.Palmitoylation by DHHC8 is essential for membrane localization. Ref.13

Involvement in disease: High density lipoprotein deficiency 1 (HDLD1) [MIM:205400]: Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.24 Ref.25 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.37 Ref.38 Ref.39 Ref.40 Ref.41 Ref.43High density lipoprotein deficiency 2 (HDLD2) [MIM:604091]: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16 Ref.17 Ref.19 Ref.21 Ref.27 Ref.28 Ref.43 Ref.44

Sequence similarities: Belongs to the ABC transporter superfamily. ABCA family.Contains 2 ABC transporter domains.

Sequence caution: The sequence AAD49849.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA10005.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.