Goat 8-Hydroxyguanosine Polyclonal Antibody
8-Hydroxyguanosine polyclonal antibody
Reactivity
GeneralPartially cross-reacts with 8-mercaptoguanosine and slightly with 8-bromoguanosine. Does not cross-react with other naturally occuring nucleotides
Applications
ELISA, Immunohistochemistry, Immunohistochemistry
Synonyms
8-Hydroxyguanosine; Polyclonal Antibody; 8-Hydroxyguanosine polyclonal antibody; anti-8-Hydroxyguanosine antibody
Host
Goat
Reactivity
General
Partially cross-reacts with 8-mercaptoguanosine and slightly with 8-bromoguanosine. Does not cross-react with other naturally occuring nucleotides
Partially cross-reacts with 8-mercaptoguanosine and slightly with 8-bromoguanosine. Does not cross-react with other naturally occuring nucleotides
Clonality
Polyclonal
Specificity
Recognizes 8-hydroxyguanosine and 8-hydroxy-2'-deoxyguanosine
Form/Format
Liquid. Neat serum
Applicable Applications for anti-8-Hydroxyguanosine antibody
ELISA (EIA), Immunohistochemistry (IHC) Frozen, Immunohistochemistry (IHC) Paraffin
Application Notes
ELISA: 1:250,000
IHC-P: 1:200
IHC-P: 1:200
Immunogen
Synthetic 8-hydroxyguanosine-conjugate
Preparation and Storage
For long term storage, store at -20 degree C. Avoid freeze/thaw cycles
Shipping: Shipped on Blue Ice
Shipping: Shipped on Blue Ice
Related Product Information for anti-8-Hydroxyguanosine antibody
8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging and neurodegenerative conditions, such as Alzheimer's disease. 8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress. Industrial uses may extend to the dietary supplement manufacturers, who could benefit from an immunoassay that could be used to test the effectiveness of antioxidants and other nutraceuticals.
Product Categories/Family for anti-8-Hydroxyguanosine antibody
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Product Notes
The 8-Hydroxyguanosine (Catalog #AAA566127) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The 8-Hydroxyguanosine polyclonal antibody reacts with General Partially cross-reacts with 8-mercaptoguanosine and slightly with 8-bromoguanosine. Does not cross-react with other naturally occuring nucleotides and may cross-react with other species as described in the data sheet. AAA Biotech's 8-Hydroxyguanosine can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC) Frozen, Immunohistochemistry (IHC) Paraffin. ELISA: 1:250,000 IHC-P: 1:200. Researchers should empirically determine the suitability of the 8-Hydroxyguanosine for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "8-Hydroxyguanosine, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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