Rabbit anti-Human, Mouse 3BP1 Polyclonal Antibody | anti-3BP1 antibody

3BP1 Polyclonal Antibody

Cat. Num. AAA8530658

• Gene Names: SH3BP1; ARHGAP43
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: 3BP1; Polyclonal Antibody; 3BP1 Polyclonal Antibody; SH3 domain-binding protein 1; 3BP-1; SH3BP1; anti-3BP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
• Sequence Length: 701

• Applicable Applications for anti-3BP1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-2000; ELISA: 1:5000-20000
• Immunogen: Synthesized peptide derived from human protein. at AA range: 170-250
• Preparation and Storage: Store at-20 degree C for 1 year.

NCBI and Uniprot Product Information

• NCBI GI #: 85815829
• NCBI GeneID: 23616
• NCBI Accession #: NP_061830.3
• NCBI GenBank Nucleotide #: NM_018957.5
• UniProt Accession #: Q9Y3L3; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9
• Molecular Weight: 77
• NCBI Official Full Name: SH3 domain-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: SH3 domain binding protein 1
• NCBI Official Symbol: SH3BP1
• NCBI Official Synonym Symbols: ARHGAP43
• NCBI Protein Information: SH3 domain-binding protein 1
• UniProt Protein Name: SH3 domain-binding protein 1
• UniProt Gene Name: SH3BP1

NCBI Description

This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017]

Uniprot Description

GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).