DNA-directed RNA polymerase II subunit GRINL1A (POLR2M) Recombinant Protein | POLR2M recombinant protein

Recombinant Human DNA-directed RNA polymerase II subunit GRINL1A (POLR2M)

Cat. Num. AAA1250835

• Gene Names: POLR2M; GCOM1; Gdown; Gdown1; GRINL1A
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DNA-directed RNA polymerase II subunit GRINL1A (POLR2M); Recombinant Human DNA-directed RNA polymerase II subunit GRINL1A (POLR2M); POLR2M recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-368, Full length protein
• Sequence: MCSLPRGFEPQAPEDLAQRSLVELREMLKRQERLLRNEKFICKLPDKGKKIFDSFAKLKAAIAECEEVRRKSELFNPVSLDCKLRQKAIAEVDVGTDKAQNSDPILDTSSLVPGCSSVDNIKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASSNRDRVPPSSEASEHHPRHRVSSQAEDTSSSFDNLFIDRLQRITIADQGEQQSEENASTKNLTGLSSGTEKKPHYMEVLEMRAKNPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF
• Sequence Length: 368

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 70166832
• NCBI GeneID: 81488
• NCBI Accession #: NP_001018112.1
• NCBI GenBank Nucleotide #: NM_001018102.2
• UniProt Accession #: P0CAP2; Q6EER8; Q6EES2; Q6EEV3; Q6EF00; Q6EF01; Q6EF02; Q6EF46; Q6EFN8; Q6EM48; Q6K046; Q6K050; Q6EEV4
• Molecular Weight: 15,131 Da
• NCBI Official Full Name: protein GRINL1A isoform 2
• NCBI Official Synonym Full Names: RNA polymerase II subunit M
• NCBI Official Symbol: POLR2M
• NCBI Official Synonym Symbols: GCOM1; Gdown; Gdown1; GRINL1A
• NCBI Protein Information: protein GRINL1A
• UniProt Protein Name: DNA-directed RNA polymerase II subunit GRINL1A
• Protein Family: DNA-directed RNA polymerase
• UniProt Gene Name: POLR2M
• UniProt Synonym Gene Names: GRINL1A

NCBI Description

This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]

Uniprot Description

Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.