Human polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa ELISA Kit | POLR2L elisa kit
Human DNA-directed RNA polymerases I, II, and III subunit RPABC5, POLR2L ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
Uniprot Description
POLR2L: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
Protein type: Transferase; DNA-binding; EC 2.7.7.6; Transcription initiation complex; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase II, core complex; cytosol; nucleus; DNA-directed RNA polymerase I complex
Molecular Function: DNA binding; zinc ion binding; DNA-directed RNA polymerase activity
Biological Process: transcription from RNA polymerase II promoter; termination of RNA polymerase III transcription; viral reproduction; somatic stem cell maintenance; positive regulation of viral transcription; regulation of gene expression, epigenetic; transcription from RNA polymerase III promoter; mRNA capping; negative regulation of gene expression, epigenetic; transcription-coupled nucleotide-excision repair; positive regulation of interferon type I production; RNA elongation from RNA polymerase III promoter; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase I promoter; RNA splicing; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; nuclear mRNA splicing, via spliceosome; nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; innate immune response; gene expression; transcription initiation from RNA polymerase I promoter
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Product Notes
The Human POLR2L polr2l (Catalog #AAA9342497) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342497 ELISA Kit recognizes Human POLR2L. It is sometimes possible for the material contained within the vial of "polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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