GDP-fucose protein O-fucosyltransferase 1 (POFUT1) Recombinant Protein | POFUT1 recombinant protein
Recombinant Pan troglodytes GDP-fucose protein O-fucosyltransferase 1 (POFUT1)
Gene Names
POFUT1; fut12
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
GDP-fucose protein O-fucosyltransferase 1 (POFUT1); Recombinant Pan troglodytes GDP-fucose protein O-fucosyltransferase 1 (POFUT1); POFUT1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
27-388, Full length protein
Sequence
GSWDPAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPTHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYREQWSQRFSPKEHPVLALPGAPAQFPVLEEHRPLQKYMVWSDEMVKTGEAQIHAHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTAAPLTMTMCLPDLKEIQRAVKLWVRSLDAQSVYVATDSESYVPELQQLFKGKVKVVSLKPEVAQVDLYILGQADHFIGNCVSSFTAFVKRERDLQGRPSSFFGMDRPPKLRDEF
Sequence Length
362
Species
Pan troglodytes (Chimpanzee)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
43,956 Da
NCBI Official Full Name
GDP-fucose protein O-fucosyltransferase 1
NCBI Official Synonym Full Names
protein O-fucosyltransferase 1
NCBI Official Symbol
POFUT1
NCBI Official Synonym Symbols
fut12
NCBI Protein Information
GDP-fucose protein O-fucosyltransferase 1
UniProt Protein Name
GDP-fucose protein O-fucosyltransferase 1
UniProt Gene Name
POFUT1
UniProt Synonym Gene Names
FUT12; O-FucT-1
Uniprot Description
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).
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Product Notes
The POFUT1 pofut1 (Catalog #AAA1368832) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-388, Full length protein. The amino acid sequence is listed below: GSWDPAGYLL YCPCMGRFGN QADHFLGSLA FAKLLNRTLA VPPWIEYQHH KPPFTNLHVS YQKYFKLEPL QAYHRVISLE DFMEKLAPTH WPPEKRVAYC FEVAAQRSPD KKTCPMKEGN PFGPFWDQFH VSFNKSELFT GISFSASYRE QWSQRFSPKE HPVLALPGAP AQFPVLEEHR PLQKYMVWSD EMVKTGEAQI HAHLVRPYVG IHLRIGSDWK NACAMLKDGT AGSHFMASPQ CVGYSRSTAA PLTMTMCLPD LKEIQRAVKL WVRSLDAQSV YVATDSESYV PELQQLFKGK VKVVSLKPEV AQVDLYILGQ ADHFIGNCVS SFTAFVKRER DLQGRPSSFF GMDRPPKLRD EF. It is sometimes possible for the material contained within the vial of "GDP-fucose protein O-fucosyltransferase 1 (POFUT1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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