Adipophilin Recombinant Protein | PLIN2 recombinant protein

Adipophilin protein

Cat. Num. AAA5304473

• Gene Names: PLIN2; ADFP; ADRP
• Purity: Adipophilin protein was purified using a a proprietary chromatographic technique.
• Synonyms: Adipophilin; Adipophilin protein; ADRP protein; Adipose differentiation-related protein; MGC10598 protein; ADFP protein; PLIN2 recombinant protein

• Host: Human
• Purity/Purification: Adipophilin protein was purified using a a proprietary chromatographic technique.
• Form/Format: Supplied in lyophilized form from 0.5 mg/ml solution containing 20mM Tris pH 7.5, and 20 mM NaCl
• Sequence Length: 437

• Protein Type: Recombinant
• Biological Significance: Adipophilin is a 49 kDa protein that belongs to the PAT family, which comprises proteins involved in the coating of lipid droplets. ADFP is expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. ADFP expression has a role in clear cell renal carcinoma differentiation. Most recently, it has been discovered that patients with kidney cancers had high levels of ADFP in their urine, suggesting that ADFP could be an excellent marker for kidney cancer.
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for PLIN2 recombinant protein

Purified recombinant Human Adipophilin protein

Product Categories/Family for PLIN2 recombinant protein

Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 1806040
• NCBI GeneID: 123
• UniProt Accession #: Q99541; Q9BSC3
• Molecular Weight: 49 kDa
• NCBI Official Full Name: adipophilin, partial
• NCBI Official Synonym Full Names: perilipin 2
• NCBI Official Symbol: PLIN2
• NCBI Official Synonym Symbols: ADFP; ADRP
• NCBI Protein Information: perilipin-2
• UniProt Protein Name: Perilipin-2
• Protein Family: Perilipin
• UniProt Gene Name: PLIN2
• UniProt Synonym Gene Names: ADFP; ADRP
• UniProt Entry Name: PLIN2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Description

perilipin 2: May be involved in development and maintenance of adipose tissue. Belongs to the perilipin family.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 9p22.1

Cellular Component: endoplasmic reticulum; extracellular region; plasma membrane; lipid particle; nucleus; cytosol

Biological Process: response to drug; long-chain fatty acid transport; sequestering of lipid; cellular lipid metabolic process; response to organic cyclic substance