Mitochondrial cardiolipin hydrolase (PLD6) Recombinant Protein | PLD6 recombinant protein

Recombinant Bovine Mitochondrial cardiolipin hydrolase (PLD6), partial

• Gene Names: PLD6; mitoPLD
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mitochondrial cardiolipin hydrolase (PLD6); Recombinant Bovine Mitochondrial cardiolipin hydrolase (PLD6); partial; PLD6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 220

• Species: Bos taurus (Bovine)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 431822421
• NCBI GeneID: 526651
• NCBI Accession #: NP_001258919.1
• NCBI GenBank Nucleotide #: NM_001271990.1
• UniProt Accession #: E1BE10
• Molecular Weight: 25,150 Da
• NCBI Official Full Name: mitochondrial cardiolipin hydrolase
• NCBI Official Synonym Full Names: phospholipase D family member 6
• NCBI Official Symbol: PLD6
• NCBI Official Synonym Symbols: mitoPLD
• NCBI Protein Information: mitochondrial cardiolipin hydrolase
• UniProt Protein Name: Mitochondrial cardiolipin hydrolase
• Protein Family: Mitochondrial cardiolipin hydrolase
• UniProt Gene Name: PLD6
• UniProt Synonym Gene Names: PLD 6

Uniprot Description

Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low. In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion ().