Mouse phospholipase D family, member 6 ELISA Kit | PLD6 elisa kit
Mouse Mitochondrial cardiolipin hydrolase, PLD6 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PLD6: Cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
Protein type: EC 3.1.4.4; Membrane protein, integral; Phospholipase; EC 3.1.4.-
Cellular Component: mitochondrial outer membrane; mitochondrion; membrane; integral to membrane
Molecular Function: nuclease activity; hydrolase activity; metal ion binding; endonuclease activity; catalytic activity; T/G mismatch-specific endonuclease activity; phosphoric ester hydrolase activity
Biological Process: meiosis; polar granule organization and biogenesis; meiotic cell cycle; metabolic process; DNA methylation during gametogenesis; spermatogenesis; lipid metabolic process; cell differentiation; lipid catabolic process; spermatid development
Research Articles on PLD6
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Product Notes
The Mouse PLD6 pld6 (Catalog #AAA9329205) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329205 ELISA Kit recognizes Mouse PLD6. It is sometimes possible for the material contained within the vial of "phospholipase D family, member 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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