Human 1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase delta 1 ELISA Kit | PLCD1 elisa kit
Human 1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase delta 1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
PLCD1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Defects in PLCD1 are the cause of nail disorder non- syndromic congenital type 3 (NDNC3). NDNC3 is a nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase
Chromosomal Location of Human Ortholog: 3p22-p21.3
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: signal transducer activity; phosphatidylserine binding; GTPase activating protein binding; calcium ion binding; phosphoinositide phospholipase C activity
Biological Process: inositol phosphate metabolic process; phospholipid metabolic process; angiogenesis; lipid catabolic process; regulation of cell proliferation
Disease: Nail Disorder, Nonsyndromic Congenital, 3
Research Articles on PLCD1
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Product Notes
The Human PLCD1 plcd1 (Catalog #AAA7235656) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7235656 ELISA Kit recognizes Human PLCD1. It is sometimes possible for the material contained within the vial of "1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase delta 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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