FCM/FACS (Flow Cytometry)
(SYTL2 Antibody (Center) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Rabbit anti-Human SYTL2 Polyclonal Antibody | anti-SYTL2 antibody
SYTL2 Antibody (Center)
Gene Names
SYTL2; EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SYTL2, Antibody; SYTL2 Antibody (Center); Synaptotagmin-like protein 2; Breast cancer-associated antigen SGA-72M; Exophilin-4; SYTL2; KIAA1597; SGA72M; SLP2; SLP2A; anti-SYTL2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SYTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-868 amino acids from the Central region of human SYTL2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
840-868
Sequence Length
934
Applicable Applications for anti-SYTL2 antibody
FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Cellular Location
Isoform 1: Cytoplasm. Cell membrane Note=Recruited on vesicular structures in cytoxic T-lymphocytes (CTL) by RAB27A.
Tissue Location
Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
FCM/FACS (Flow Cytometry)
(SYTL2 Antibody (Center) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
FCM/FACS (Flow Cytometry)
(SYTL2 Antibody (Center) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
IHC (Immunohiostchemistry)
(SYTL2 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SYTL2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(SYTL2 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SYTL2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(Western blot analysis of SYTL2 Antibody (Center) in Hela cell line lysates (35ug/lane). SYTL2 (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of SYTL2 Antibody (Center) in Hela cell line lysates (35ug/lane). SYTL2 (arrow) was detected using the purified Pab.)
Related Product Information for anti-SYTL2 antibody
SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery.
Product Categories/Family for anti-SYTL2 antibody
References
Menasche, G., et al. Blood 112(13):5052-5062(2008)
Kesari, A., et al. Am. J. Pathol. 173(5):1476-1487(2008)
Chavas, L.M., et al. Structure 16(10):1468-1477(2008)
Kesari, A., et al. Am. J. Pathol. 173(5):1476-1487(2008)
Chavas, L.M., et al. Structure 16(10):1468-1477(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
104930
NCBI Official Full Name
synaptotagmin-like protein 2 isoform g
NCBI Official Synonym Full Names
synaptotagmin-like 2
NCBI Official Symbol
SYTL2
NCBI Official Synonym Symbols
EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
NCBI Protein Information
synaptotagmin-like protein 2
UniProt Protein Name
Synaptotagmin-like protein 2
UniProt Gene Name
SYTL2
UniProt Synonym Gene Names
KIAA1597; SGA72M; SLP2; SLP2A
UniProt Entry Name
SYTL2_HUMAN
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Product Notes
The SYTL2 sytl2 (Catalog #AAA288221) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 840-868. The SYTL2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SYTL2 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the SYTL2 sytl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SYTL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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