Plant Thrombopoietin Receptor Antibody (Anti-TPOR) ELISA Kit | Anti-TPOR elisa kit
Plant Thrombopoietin Receptor Antibody (Anti-TPOR) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
Uniprot Description
THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Secreted; Secreted, signal peptide; Cytokine
Chromosomal Location of Human Ortholog: 3q27
Molecular Function: growth factor activity
Biological Process: multicellular organismal development; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade
Disease: Thrombocythemia 1
Research Articles on Anti-TPOR
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Product Notes
The Plant Anti-TPOR thpo (Catalog #AAA9375997) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9375997 ELISA Kit recognizes Plant Anti-TPOR. It is sometimes possible for the material contained within the vial of "Thrombopoietin Receptor Antibody (Anti-TPOR), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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