Plant Ephrin Type B Receptor 3 (EPHB3) ELISA Kit | EPHB3 elisa kit

Plant Ephrin Type B Receptor 3 (EPHB3) ELISA Kit

• Gene Names: EPHB3; EK2; ETK2; HEK2; TYRO6
• Reactivity: Plant
• Synonyms: Ephrin Type B Receptor 3 (EPHB3); Plant Ephrin Type B Receptor 3 (EPHB3) ELISA Kit; EPHB3 elisa kit

• Reactivity: Plant
• Sequence Length: 998

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 17975768
• NCBI GeneID: 2049
• NCBI Accession #: NP_004434.2
• NCBI GenBank Nucleotide #: NM_004443.3
• Molecular Weight: 110,330 Da
• NCBI Official Full Name: ephrin type-B receptor 3
• NCBI Official Synonym Full Names: EPH receptor B3
• NCBI Official Symbol: EPHB3
• NCBI Official Synonym Symbols: EK2; ETK2; HEK2; TYRO6
• NCBI Protein Information: ephrin type-B receptor 3
• UniProt Protein Name: Ephrin type-B receptor 3
• Protein Family: Ephrin type-B receptor
• UniProt Gene Name: EPHB3
• UniProt Synonym Gene Names: ETK2; HEK2; TYRO6; EPH-like kinase 2; EK2; hEK2
• UniProt Entry Name: EPHB3_HUMAN

NCBI Description

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]

Uniprot Description

EphB3: a ubiquitous receptor tyrosine kinase of the Eph family. A receptor for ephrin-B family members: ephrin-B1 and -B2. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.EphB3 contains 1 sterile alpha motif (SAM) domain and 2 fibronectin type III domains.

Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Eph family

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: cytosol; extracellular region; integral to plasma membrane; plasma membrane

Molecular Function: ephrin receptor activity

Biological Process: angiogenesis; axon guidance; axonal fasciculation; cell migration; corpus callosum development; digestive tract morphogenesis; ephrin receptor signaling pathway; palate development; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of axonogenesis; regulation of cell-cell adhesion; regulation of GTPase activity; thymus development; urogenital system development